<i>N</i> ‐acetylcysteine as a new prominent approach for treating psychiatric disorders

نویسندگان

چکیده

N-acetylcysteine (NAC) is a well-known and safe mucolytic agent, also used in patients with paracetamol overdose. In addition to these effects, recent preclinical clinical studies have shown that NAC exerts beneficial effects on different psychiatric disorders. Many potential mechanisms been proposed underlie the therapeutic of NAC, including regulation several neurotransmitters, oxidative homeostasis, inflammatory mediators. this paper, we summarize current knowledge ability ameliorate symptoms neuropathologies related disorders, attention deficit hyperactivity disorder, anxiety, bipolar depression, obsessive–compulsive obsessive–compulsive-related posttraumatic stress schizophrenia. Although positive effect animal models efficacy not fully established. remains strong candidate for adjunct treatment many but additional are needed.

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ژورنال

عنوان ژورنال: British Journal of Pharmacology

سال: 2021

ISSN: ['0007-1188', '1476-5381']

DOI: https://doi.org/10.1111/bph.15456